Frontline Plus X-Large Dogs 88-132lbs(40-60kg), 3 Pack

Premium Monthly Flea & Tick Treatment and Prevention

Protect your giant breed dog with Frontline Plus, the #1 veterinarian-recommended topical treatment for fast, long-lasting control of fleas, ticks, and chewing lice. This non-systemic, water-resistant formula kills 98–100% of fleas within 24 hours and ticks within 48 hours, while preventing all flea life stages (eggs, larvae, pupae) from developing—breaking the flea life cycle and protecting your home from infestation.

Key features

• Fast-acting flea & tick control – Kills 98–100% of fleas within 24 hours and ticks within 48 hours of application.

• Breaks the flea life cycle – Prevents flea eggs, larvae, and pupae from developing, stopping reinfestation in your home.

• Long-lasting protection – Continues to kill fleas for up to 2 months and ticks for up to 1 month with a single monthly application.

• Water-resistant formula – Effective even after bathing, shampooing, or swimming (once dry).

• Non-systemic topical treatment – Works on the skin's surface without entering the bloodstream; safe for dogs and puppies 8 weeks and older.

• Aids in flea allergy dermatitis control – Reduces itching and irritation caused by flea bites.

• Effective against sarcoptic mange – Helps control mite infestations in addition to fleas and ticks.

Specifications

• Brand: Frontline Plus (Merial, a Boehringer Ingelheim company)

• Product name: Frontline Plus for Extra Large Dogs 88–132 lbs (40–60 kg)

• Active ingredients:

  • Fipronil: 9.8% w/v (kills adult fleas, ticks, and chewing lice)

  • (S)-Methoprene: 8.8% w/v (insect growth regulator that prevents flea eggs, larvae, and pupae from developing)

• Dosage: 1 pipette (4.02 ml) per dog per month

• Weight range: 88–132 lbs (40–60 kg)

• Pack size: 3 pipettes (3-month supply)

• Application: Topical spot-on (between shoulder blades)

• Age suitability: 8 weeks and older

• Color coding: Extra-large dogs (purple or gray packaging, depending on region)

• Water resistance: Effective after bathing/shampooing once dry; avoid bathing 48 hours before or after application

• Storage: Store at room temperature (20–25°C / 68–77°F); keep in original packaging

• Prescription required: No (available over-the-counter in most regions)

Benefits

• Rapid flea & tick elimination – Kills fleas within 24 hours and ticks within 48 hours, reducing disease transmission risk (e.g., Lyme disease from deer ticks).

• Prevents home infestation – Stops flea reproduction by killing eggs, larvae, and pupae, protecting carpets, bedding, and furniture.

• Extended protection – Continues killing fleas for up to 2 months and ticks for up to 1 month with monthly reapplication.

• Water-resistant – Remains effective after bathing, swimming, or rain exposure (once dry).

• Safe for all ages – Suitable for puppies 8 weeks and older, as well as senior dogs.

• Non-systemic formula – Works on the skin's surface without entering the bloodstream, minimizing systemic side effects.

• Aids in managing skin conditions – Helps control flea allergic dermatitis and sarcoptic mange.

Ideal for

• Extra-large breed dogs (88–132 lbs / 40–60 kg):

  • Great Danes, Mastiffs, Saint Bernards, Newfoundlands, Irish Wolfhounds, Leonbergers, Tibetan Mastiffs

• Dogs with:

  • Active flea or tick infestations

  • Flea allergy dermatitis or itchy skin

  • Exposure to outdoor environments (parks, trails, yards)

  • Multi-pet households needing comprehensive parasite control

• Year-round prevention in:

  • Warm, humid climates with high flea/tick activity

  • Seasonal peaks (spring, summer, fall)

  • Indoor/outdoor dogs requiring continuous protection

Method of application

1. Prepare the pipette:

   • Remove one pipette from the blister pack.

   • Hold upright with the foil side toward you.

   • Snap the tip off along the score line (away from your face and body).

2. Apply to the skin:

   • Part your dog's hair between the shoulder blades until the skin is visible.

   • Place the pipette tip directly on the skin (not on the fur).

   • Squeeze gently to empty the entire contents in one or two spots.

3. After application:

   • Avoid touching the application site until dry (approx. 24 hours).

   • Do not bathe, shampoo, or allow swimming for 48 hours before or after application.

   • Keep treated dogs away from soft furnishings or varnished surfaces until dry to prevent staining.

4. Frequency: Apply once every 30 days for continuous protection.

Important safety information

• For external use only – Do not administer orally or apply to broken skin.

• Age restriction: Not for use on puppies under 8 weeks of age.

• Weight-specific dosing: Use only the correct pipette size for your dog's weight (88–132 lbs / 40–60 kg).

• Bathing guidelines: Avoid bathing or shampooing 48 hours before or after application; water resistance is maintained once dry.

• Side effects (rare): Mild, temporary skin irritation (redness, itching, or hair loss) may occur at the application site. Contact your veterinarian if symptoms persist.

• Human safety: Wash hands after application. Keep out of reach of children.

• Multi-pet households: Treat all dogs and cats in the home simultaneously to prevent cross-infestation.

• Storage: Store in a cool, dry place away from direct sunlight and heat.

Why choose Frontline Plus?

• Trusted brand – #1 veterinarian-recommended flea and tick treatment for over 25 years.

• Dual-action formula – Combines fipronil (adulticide) and (S)-methoprene (insect growth regulator) for comprehensive protection.

• Fast & long-lasting – Kills fleas within 24 hours and provides up to 2 months of continuous protection.

• Water-resistant – Effective even after bathing, swimming, or rain exposure.

• Non-systemic safety – Works on the skin's surface without entering the bloodstream, minimizing systemic side effects.

Package includes

• 3 × Frontline Plus pipettes (4.02 ml each, for extra-large dogs 88–132 lbs)

• 1 × Product information leaflet & safety guide

Tips for best results

• Consistency is critical: Apply monthly, year-round, to maintain uninterrupted protection.

• Treat all pets: Ensure all dogs and cats in the household are treated simultaneously to prevent reinfestation.

• Combine with environmental control: Vacuum carpets, wash bedding, and use flea sprays in the home for severe infestations.

• Monitor for ticks: Check your dog regularly, especially after outdoor activities, and remove any ticks promptly.

• Consult your vet: If your dog has a history of skin sensitivities or medical conditions, discuss use with your veterinarian before starting treatment.

A premium, vet-trusted solution for comprehensive flea and tick control—giving your extra-large dog the protection they deserve against parasites and the diseases they carry.

Shipping (8–14 business days)

If for any reason you are not happy with your purchase, you may return the item(s) within 15 days of receiving the order. Please note that monogrammed, personalized, special-order items and items damaged through normal wear and tear are not eligible for return. Products must be returned in new condition so they can be sold to the next customer. If this is not the case, a refund will not be issued.